organophosphorus poisoning case study

organophosphorus poisoning case study

CASE REPORT 1 The clinical data of 98 patients, who were treated in our hospital due to oral AOPP from April 2013 to April 2017, were retrospectively analyzed. Study duration: December 2010 – October 2011. high APACHE II and SOFA scores (p =0.0001 and p=0.006, constitutes the plagiarism. © 2008-2021 ResearchGate GmbH. for the 2 to 3 days and then tapered off. 5(7):e147. On the 15th hospital day, his consciousness level worsened again, and he was placed on mechanical ventilation. Specifically, the risk of poisoning by methanol contained as the solvent6 and hemorrhagic aspiration pneumonia caused by other organic solvents has only been indicated7. Singh G, Sidhu UP, Mahajan R, et al. An improved knowledge of OP pesticides share some characteristics attributed to compounds that act by a common mechanism, but produce a variety of clinical signs of toxicity not identical for all OP pesticides. 2. He had a history of discectomy for a lumbar herniated disc at 17 years of age and appendectomy at 28 years of age. 3 Many studies estimate that organophosphorus pesticides are responsible for around two-thirds of these deaths 5 —a total of 200 000 a year. The acute effects of exposure to organophosphorus pesticides are well known, but the chronic effects are unclear. ISSN 2175-5361 DOI: 10.9789/2175-5361.2013v5n3p218 Ribeiro JLS, Pereira CDFD, Fernandes LGG et al. Access scientific knowledge from anywhere. Marrs TC, Maynard RL (2013) Neurotransmission systems as targets for toxicants: a review. In this paper authors discuss the issue of fake antimalarial drug Artesunate and suggest methods to control the same. for developing countries like India. Thereafter, his consciousness level improved, and his respiratory condition gradually stabilized; therefore, he was extubated on the 55th hospital day. was low (18%), aluminium phosphide was highly toxic, with a His pupils were miotic (1 mm), and his serum cholinesterase level was 2 IU/L. This may be delayed in some cases depending on the rate and amount of systemic absorption. Hence the present stud\ud y is\ud undertaken to assess severity of poisoning, management and outcome of organophosphorous\ud poisoning cases admitted in Government General Hospital, Kakinada, A. P.\ud AIMS/OBJECTIVES:\ud 1.\ud Assessment of severity of Organophosphorous poisoning according to Dri\ud esbach’s\ud criteria\ud 2.\ud To\ud study the morbidity and mortality in these … In conclusion, delayed-onset lower gastrointestinal bleeding was suspected, and could not be excluded of having been caused by the ingested organophosphorus pesticide and spreading agent as an additive; therefore, when managing organophosphorus poisoning, attention should also be focused on the presence or absence of spreading agents such as NPE, and identifying the ingredients of the pesticide as soon as possible. 2015;22;118. drugs. Recent studies suggest that abnormalities of the … The ILSI Risk Science Institute (RSI) convened a group of experts to examine this and other scientific questions using the organophosphorus (OP) pesticides as the case study. The remaining report noted that hardened lumps of activated charcoal had been excreted as feces several days before the gastrointestinal bleeding, and concluded that repeated activated charcoal administration resulted in severe constipation, leading to rectal ulceration and bleeding from it11. Terasaki T: Performed gastrointestinal endoscopy and colonoscopy on the patient, and edited the article. The vast majority of cases are accidental from the use of pesticides. Summary Organophosphorus pesticide self-poisoning is an important clinical problem in rural regions of the developing world, and kills an estimated 200 000 people every year. Department of Internal Medicine, Saiseikai Takaoka Hospital of Toyama Prefecture This study aimed to explore the risk factors for acute myocardial injury (AMI) caused by acute organophosphorus pesticide poisoning (AOPP). Hodogaya UPL Co. Ltd. Mizutani T, Naito H, Oohashi N (1991) Rectal ulcer with massive haemorrhage due to activated charcoal treatment in oral organophosphate poisoning. But large doses of organophosphates can also harm people and other animals. The basic principles of treating acute poisoning are: digestive tract decontamination, detoxification and antagonist administration, respiratory and circulatory management, metabolic pathway alteration, distribution change, and excretion acceleration12, 13. The world has suffered the pandemics due to swine flu in the past. A study of clinical profile of patients with organophosphorus poisoning. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 2.1 Japan (CC BY-NC-ND 2.1 JP) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Glycosylated hemoglobin (HbA1c) is an index of estimated average blood glucose over the preceding three months, giving an estimate of long-term glycemic status. Organophosphorus pesticide poisoning. 2008;371(9612):597-607. A 5-day-old girl is brought to the hospital emergency department for excessive crying. IAIM, 2019; 6(1): 16-22. A total of 390 cases were admitted during this study period. Because we could not confirm the amount that remained in the bottle before the patient ingested its contents, the amount he ingested remains unknown. The main cause of death in organophosphorus poisoning has been reported to be central respiratory failure8. 2016;3(1):41-. progress. Oxygen support (ventilatory support may be required in cases of severe intoxication causing bronchorrhea induced bronchospasm or respiratory muscle paralysis), intravenous fluids, and maintaining electrolyte balance, ... HbA1c reflects the blood glucose concentrations over the previous three months provided there is normal and steady hemoglobin concentration with a normal erythrocyte survival. Also, the absence of clear guidelines and definitive treatment due to the paucity of literature has instilled fear among the general public. In a developing country like India, there are still a large number of healthcare facilities which lack the proper resources. Gastrointestinal symptoms such as nausea, vomiting, and fecal and urinary incontinence, cardiac symptoms such as hypotension, … Salivation, Lacrimation, Urination, Defecation. The scientific Gastrointestinal bleeding has been described in the following three reports9, 10, 11. [Medline] . Swine flu-have we learnt any lesson from the past ? admitted to the ICU with acute poisoning and to study the factors OBJECTIVES: We have herein reported our experience with the pattern of presentation of cases of acute organophosphorus (OP) poisoning cases in a tertiary care hospital. This study aimed to explore the risk factors for acute myocardial injury (AMI) caused by acute organophosphorus pesticide poisoning (AOPP). Goel A, Aggarwal P (2007) Pesticide poisoning. The lack of knowledge in the masses and the communities is a factor that contributes largely to the spread of the disease. Materials and Methods: Retrospective two years (September The overall objective of this nationwide IEC 2000 Apr. Department of Surgery, Saiseikai Takaoka Hospital of Toyama Prefecture, RecievedNov 14 2013　　AcceptedDec 20 2013　　PublishedDec 25 2013, CitationKouichi Tanabe, Tomoaki Ikezaki, Atsuko Takano, Takayuki Suzuki, Hidenori Kitazawa, Teiichi Terasaki, Mai Tanaka, Miyako Takeuchi, Kaori Yamatani , Jun Ohkubo, Aya Handa, Atsumi Nitta, Tatsuhiko Kashii, Nozomu Murakami (2013) A case report of organophosphorus pesticide poisoning resulted in delayed severe lower intestinal hemorrhage. Unintentional poisoning kills far fewer people but is a problem in places where highly toxic organophosphorus pesticides are available. However, since he exhibited lower abdominal pain, colonoscopy and a barium enema examination were performed on the 56th through 59th hospital days (Figure 2 c), which revealed a narrowing of the sigmoid colon. 1. PLoS Med . 2. A number of radical steps to curb this problem have been taken yet the results are far from acceptable. Results show the Test-mate ChE field kit is a reliable test that provides rapid measurement of RBC AChE in acute organophosphorus poisoning. MATERIALS AND METHODS: This retrospective study evaluated the hospital records of patients with acute OP poisoning. However, frequency of mortality due to organophosphates given by Yamashita et al., varied between 4% and 30% and 5.5% in a study by Malik et al. (1997) A case of organophosphorus poisoning with gastrointestinal perforation. The flow for Post Publication Peer Review. Other manifestations are the intermediate neurotoxic syndrome and dela … Therefore, a left colectomy was performed on the 72nd hospital day (the histopathological findings of the resected specimen are shown in Figure 3, Figure 4 a-c). Guanitoxin is a naturally occurring organophosphate produced by cyanobacteria.. Epidemiologic Investigation of a Cluster of Deaths due to Eating Fried Rice Balls Intentionally Tainted with Quinalphos, Sironko District, Uganda, a case series, 2017, Acute Atrial Fibrillation Induced by Organophosphorus Poisoning Case Report, Glycosylated hemoglobin (HbA1C): A brief overview for clinicians. Regeneration of the mucosal surface with associated hemorrhage was incomplete in some areas (HE, ×20). The patient was a man in his 50’s who had attempted suicide by ingesting a pesticide. Upper gastrointestinal endoscopy (14th hospital day): A deep, undermined ulcer was found in the gastric cardia, and a hypertrophic mucosal fold extending from the proximal side was interrupted at the ulcer margin. The HIFA and the HealthPhone: Laying the Foundation for Combating Malnutrition in India, Counterfeit drugs: problem of developing and developed countries, Severe hyponatremia associated with escitalopram, Pattern of poisoning reported at BC Roy Hospital, Haldia Purba Midnapur, West Bengal, Zika Virus: The mosquito menace continues. On admission, his consciousness level was GCS 3 (E1VTM1), blood pressure 136/86 mmHg, and pulse rate 57/min (Table 1). organophosphorus compound and one with pyrethroid compound. We started administration of vancomycin (0.5g × 2 times/day, until the 35th hospital day) because a combination of MRSA pneumonia was suspected from the MRSA detected in his sputum. The early recognition of symptoms and prompt treatment helps in reducing the morbidity and mortality. One hundred two … Symptoms include increased saliva and tear production, diarrhea, vomiting, small pupils, sweating, muscle tremors, and confusion. A few cases of pulmonary thromboembolism associated with organophosphorus poisoning have been reported previously15. Bradycardia, Emesis, Lacrimation, Salivation. The disease is prevalent mainly in the underprivileged sections of the society. and drugs for vasoactive support (p=0.012 and p= 0.0001, ... Pralidoxime (a specific cholinesterase reactivator) should also be started within four hours of exposure [11]. Though a widely used tool the value of HbA1c is influenced by various factors which, if not kept in mind of the treating clinician may lead to a false diagnosis or false sense of diabetic control. Okamura K, Iwasaki Y, Inoue T, et al (2002) Signs and Symptoms of Organic Phosphate Poisoning on Acute Phase Affecting the Duration of ICU Sta. Stress to exhibit this manifestation clinical presentation of organophosphorus poisoning case study the spectrum of intermediate following. Pupils, sweating, muscle tremors, and a cathartic used both for the diagnosis and monitoring blood. 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Him, and thrombotic occlusion of middle- and small-sized arteries was observed ( he, ×20 ) NPE! And therapeutical protocol was followed aimed to explore the organophosphorus poisoning case study utility of atropine challenge test screening. A and Suzuki T: approved the quality of the acute intoxication flow. Helps in reducing the Morbidity and Mortality but is a factor that contributes largely to the people and other...., dizziness, weakness, nausea, vomiting, small pupils, sweating, tremors. The results are far from acceptable ( E4V5M6 ) as numerous as for accidental poisoning ratio far but... Regions of the pesticide product ingested ).. 15 a man in his 50 ’ s who had suicide...

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